Today, job performance and factors affecting it are one of the important issues in the field of management in organizations. For this purpose, this research attempts to analyze the impact of HRM activities and adherence to Islamic values on job performance with the mediating role of job satisfaction. This research is descriptive and applied. The statistical population of the study consisted of all administrative staff of Zanjan University which according to the Cochran formula, the sample size was determined 200. The data were collected by using questionnaire, and convenient sampling method. The reliability of the questionnaire was approved by using Cronbach alpha coefficient. Content validity is used for approving questionnaire validity. For analysis data, SEM (Structural Equation Modeling) and AMOS software were used. Findings shows that adherence to Islamic values job satisfaction and have a significant effect on job performance. In addition, HRM activities have a significant relationship with job satisfaction and has a significant effect on job performance. The effect of adherence to Islamic values on job satisfaction has been confirmed. Considering the mediating role of job satisfaction, organization managers should pay more attention to this category. Adherence to Islamic values as an effective factor on job satisfaction and performance can be taken into consideration in interviews and employment tests.